Molecular and Cell Biology Lecture 2 Replication of DNA Pt2 Stimulation of cell division by EGF

Speaking of cell division we briefly discuss one of the factors that initiates cell division using the epidermal growth factor EGF signaling pathway as an example. This signaling pathway begins when EGF binds to its receptor EGFR a transmembrane protein located on the cell surface. Following the signal inside the cell we discuss dimerization of EGFR and then its autophosphorylation and the recruitment of adaptor proteins GRB2 and SOS which activate the RAS-RAF-MEK-ERK MAPK cascade to promote cell proliferation via transcription factors such as ...

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